Shelf life (days): 1460.0
Formulation: A solid
Formal Name: (S)-1-((S)-3-mercapto-2-methylpropanoyl)pyrrolidine-2-carboxylic-2,5,5-d3 acid
Purity: ≥99% deuterated forms (d1-d3)
Formula Markup: C9H12D3NO3S
Formula Weight: 220.30452
CAS Number: 1356383-38-4
Notes: Captopril-d3 is intended for use as an internal standard for the quantification of captopril (Item No. 15313) by GC- or LC-MS. Captopril is a first generation nonpeptidic ACE inhibitor (IC50 = 6.3 nM) that was designed based on bradykinin-potentiating peptides isolated from the venom of B. jararaca, a pit viper native to Brazil. {25198,25199,25197} It does not exhibit a domain preference for binding either the C- or N-terminal active sites of the somatic form of ACE.{25198} Acute and chronic administration of captopril reduces blood pressure in spontaneously hypertensive Wistar-Kyoto rats and does not induce hypotension in salt-repleted normotensive Wistar-Kyoto rats.{42208} Captopril is also a competitive and reversible inhibitor of leukotriene (LTA4) hydrolase, which results in the disruption of LTB4 synthesis with an IC50 value of 14 μM.{25196}
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