Shelf life (days): 1460.0
Formulation: A solid
Formal Name: (SP-4-2)-diammine[1,1-cyclobutanedicarboxylato(2-)-?O,?O'']-platinum-d4
Purity: ≥99% deuterated forms (d1-d4)
Formula Markup: C6H8D4N2O4Pt
Formula Weight: 375.2728
Notes: Carboplatin-d4 is intended for use as an internal standard for the quantification of carboplatin (Item No. 13112) by GC- or LC-MS. Carboplatin is a platinum-containing DNA-crosslinking agent.{64047} It induces the formation of DNA interstrand crosslinks and DNA-protein crosslinks when used at concentrations of 200 and 300 µM. It inhibits the proliferation of GLC-4 small cell lung carcinoma and A2780 and SKOV3 ovarian cancer cells (IC50s = 22.7, 0.5, and 10.2 µM, respectively).{24627,24628} Carboplatin reduces tumor growth in an ADJ/PC6 murine plasmacytoma model (ED90 = 0.6 mg/kg, i.p.).{32401} Formulations containing carboplatin have been used in the treatment of ovarian cancer.
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