Shelf life (days): 1460.0
Formulation: A solid
Formal Name: (aS)-a-[[2-(4-morpholinyl-2,2,3,3,5,5,6,6-d8)acetyl]amino]benzenebutanoyl-L-leucyl-N-[(1S)-3-methyl-1-[[(2R)-2-methyl-2-oxiranyl]carbonyl]butyl]-L-phenylalaninamide
Purity: ≥99% deuterated forms (d1-d8)
Formula Markup: C40H49D8N5O7
Formula Weight: 728.0
CAS Number: 1537187-53-3
Notes: Carfilzomib-d8 is intended for use as an internal standard for the quantification of carfilzomib (Item No. 17554) by GC- or LC-MS. Carfilzomib is an irreversible proteosome inhibitor classified as a peptide epoxyketone. It targets the chymotrypsin-like β5 subunit of the constitutive 20S proteasome (IC50 = 5.2 nM) and the β5i subunit of the immunoproteasome 20Si (LMP7; IC50 = 14 nM) with minimal cross reactivity to other proteases.{28244,28242} It can induce cell cycle arrest and apoptosis in human cancer cell lines including multiple myeloma, lymphoma, and various solid tumors (IC50s = 2.4-20 nM).{25593,28537}
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