Shelf life (days): 1460.0
Formulation: A solid
Formal Name: (6R,7R)-3-((carbamoyloxy)methyl)-7-((Z)-2-(furan-2-yl)-2-((methoxy-d3)imino)acetamido)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Purity: ≥99% deuterated forms (d1-d3)
Formula Markup: C16H13D3N4O8S
Formula Weight: 427.40458
CAS Number: 1803240-98-3
Notes: Cefuroxime-d3 is intended for use as an internal standard for the quantification of cefuroxime (Item No. 23627) by GC- or LC-MS. Cefuroxime is a cephalosporin antibiotic with broad-spectrum activity against Gram-positive and Gram-negative bacteria including S. pyogenes, S. pneumoniae, S. viridans, E. coli, P. mirabilis, H. influenzae, and N. gonorrhoeae (mean MICs = 0.005-8.2 μg/ml).{40366} Like other cephalosporins, cefuroxime inhibits peptidoglycan crosslinking and bacterial cell wall synthesis.{40367} It is resistant to hydrolysis by bacterial β-lactamases, increasing its efficacy against β-lactamase-producing Gram-negative bacteria.{40368} Cefuroxime is protective against Gram-positive and Gram-negative infections in vivo with mean ED50 values ranging from 2 to 35 and 1 to 55 mg/kg, in mice and rats, respectively.{40369} Formulations containing cefuroxime have been used to treat urinary tract infections.
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