Shelf life (days): 1460.0
Formulation: A solid
Formal Name: N1,N14-bis(4-chlorophenyl-d4)-3,12-diimino-2,4,11,13-tetraazatetradecanediimidamide, dihydrochloride
Purity: ≥99% deuterated forms (d1-d8)
Formula Markup: C22H22Cl2D8N10 / 2HCl
Formula Weight: 586.41616
CAS Number: 2012598-75-1
Notes: Chlorhexidine-d8 is intended for use as an internal standard for the quantification of chlorhexidine (Item Nos. 17343 / 26924) by GC- or LC-MS. Chlorhexidine is a bis(biguanide) antimicrobial disinfectant and antiseptic agent.{47176} It inhibits growth of clinical methicillin-resistant S. aureus (MRSA) isolates (MIC90 = 4 μg/ml).{47177} It is also active against canine isolates of MRSA, methicillin-susceptible S. aureus (MSSA), methicillin-resistant S. pseudintermedius (MRSP), and methicillin-susceptible S. pseudintermedius (MSSP; MIC90s = 4, 2, 2, and 1 mg/L, respectively).{47178} Chlorhexidine inhibits growth of E. faecium strains (MICs = 1.2-19.6 μg/ml) and C. albicans (MIC = 5.15 μg/ml).{47179,47180} It generates cations that bind to and destabilize the bacterial cell wall to induce death.{47181} Chlorhexidine also completely inhibits matrix metalloproteinase-2 (MMP-2) and MMP-9 when used at concentrations of 0.0001 and 0.002%, respectively, in a gelatin degradation assay.{28418} Formulations containing chlorhexidine have been used in antiseptic wound dressings, mouthwash, and toothpaste.
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