Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 6-(cyclohexyl-d11)-1-hydroxy-4-methyl-2(1H)-pyridinone, monosodium salt
Purity: ≥99% deuterated forms (d1-d11)
Formula Markup: C12H5D11NO2 / Na
Formula Weight: 240.31741
Notes: Ciclopirox-d11 (sodium salt) is intended for use as an internal standard for the quantification of ciclopirox (Item No. 16021) by GC- or LC-MS. Ciclopirox is an iron chelator, antifungal, and anticancer agent.{26941,41490,53131,53132} It inhibits the iron-dependent enzyme prolyl hydroxylase 2 (PHD2; IC50 = 1.58 μM), an effect that is reduced in the presence of iron.{26941} It stabilizes hypoxia-inducible factor-α (HIF-1α) under normoxic conditions in rat glomus cells when used at a concentration of 5 μM.{33213} Ciclopirox is active against clinical isolates of T. rubrum, T. mentagrophytes, and C. albicans (MICs = 0.03-0.5, 0.03-0.5, and 0.06-0.5 μg/ml, respectively) and inhibits growth of T. mentagrophytes on porcine skin ex vivo when applied topically.{41490,53131} It inhibits proliferation of Rh30, HT-29, and MDA-MB-231 cells in a concentration-dependent manner and halts the cell cycle at the G1/G0 phase and induces apoptosis in Rh30 cells.{53132} Ciclopirox (25 mg/kg) reduces tumor growth in an MDA-MB-231 mouse xenograft model. Formulations containing ciclopirox have been used in the topical treatment of fungal infections.
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