Shelf life (days): 1460.0
Formulation: A solid
Formal Name: (Z)-7-((2-(amino-15N)-2-carboxyethyl-1,1,2-d3)thio)-2-((S)-2,2-dimethylcyclopropane-1-carboxamido)hept-2-enoic acid
Purity: ≥99% deuterated forms(d1-d3); ≤1% d0
Formula Markup: C16H23D3N[15N]O5S
Formula Weight: 362.5
CAS Number: 2738376-83-3
Notes: Cilastatin-15N-d3 is intended for use as an internal standard for the quantification of cilastatin (Item No. 23511) by GC- or LC-MS. Cilastatin is an inhibitor of dipeptidase (dehydropeptidase I), a renal dipeptidase.{36366} It inhibits human renal dipeptidase (Ki = 0.7 μM), porcine dipeptidase (IC50 = 0.11 μM), and bacterial metallo-β-lactamase CphA from A. hydrophila (IC50 = 178 μM).{36366,36367,36368} Cilastatin (200 μg/ml) protects primary porcine renal proximal tubular epithelial cells from nephrotoxicity and apoptosis induced by vancomycin (Item No. 15327).{36369} In a mouse model of systemic infection, cilastatin in combination with imipenem (Item No. 16039) protects mice from S. aureus, E. coli, and P. aeruginosa infection.{36370} Cilastatin was designed to inhibit renal metabolism of imipenem and prolong its half-life.{36367} Formulations containing cilastatin in combination with imipenem have been used to treat susceptible bacterial infections.
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