Shelf life (days): 1460.0
Formulation: A solid
Formal Name: (2S,5R,6R)-6-(3-(2-chlorophenyl)-5-(methyl-13C)isoxazole-4-carboxamido-13C)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate, monosodium salt
Purity: ≥95%
Formula Markup: C15[13C4]H17ClN3O5S / Na
Formula Weight: 461.8
Notes: Cloxacillin-13C4 is intended for use as an internal standard for the quantification of cloxacillin (Item No. 22249) by GC- or LC-MS. Cloxacillin is a β-lactam antibiotic and a derivative of oxacillin (Item No. 23954).{52188} It is active against clinical isolates of the Gram-positive bacteria S. aureus and S. epidermidis (MICs = 0.004-0.4 and 0.1-0.8 µg/ml, respectively) but not 34 Gram-negative bacteria (MICs = >128 µg/ml for all).{52188},{39101} Cloxacillin binds to S. aureus penicillin-binding protein 1 (PBP1), PBP2, PBP3, and PBP4 (IC50s = 0.04, 0.12, 0.21, and 2.5 µg/ml, respectively).{52189} It also binds to recombinant type Ib penicillinase, as well as P. vulgaris and C. freundii cephalosporinase (Kis = 15, 0.27, and 0.027 µM, respectively).{39103} Cloxacillin decreases the number of staphylococci in the mammary gland in a mouse model of acute, but not chronic, mastitis induced by Staphylococcus infection.{52190}
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