CX-5461, CAS 1138549-36-6

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: 2-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-N-[(5-methyl-2-pyrazinyl)methyl]-5-oxo-5H-benzothiazolo[3,2-a][1,8]naphthyridine-6-carboxamide

Purity: ≥98%

Formula Markup: C27H27N7O2S

Formula Weight: 513.6

CAS Number: 1138549-36-6

Notes: CX-5461 is an inhibitor of ribosomal RNA (rRNA) synthesis. It selectively inhibits RNA polymerase I-driven transcription of rRNA in HCT116, A375, and MIA PaCa-2 tumor cells (IC50s = 142, 113, and 54 nM, respectively) without affecting RNA polymerase II (IC50 > 25µM), DNA replication, or protein translation.{30876,30877} At 50 mg/kg, CX-5461 demonstrates in vivo antitumor activity against human solid tumors in mouse xenograft models.{30876}

• SKU: CAY18392-10
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 18392-10
• Package Unit: 10 mg
• Quantity Unit: STK
• Application: Reinstoffe, Isotopenmarkierung