Shelf life (days): 1460.0
Formulation: A solid
Formal Name: N,N-bis(2-chloroethyl)tetrahydro-4,5-d2-2H-1,3,2-oxazaphosphorin-4,5-d2-2-amine 2-oxide
Purity: ≥99% deuterated forms (d1-d4)
Formula Markup: C7H11Cl2D4N2O2P
Formula Weight: 265.1
CAS Number: 173547-45-0
Notes: Cyclophosphamide-d4 is intended for use as an internal standard for the quantification of cyclophosphamide (Item No. 13849) by GC- or LC-MS. Cyclophosphamide is a nitrogen mustard alkylating agent.{60549} It acts as a prodrug and is converted to the active metabolite phosphoramide mustard (Item No. 34078) via 4-hydroxycyclophosphamide and aldophosphamide intermediates by cytochrome P450s (CYP450s) in the liver. Cyclophosphamide (50 mg/kg) induces the formation of DNA interstrand crosslinks in leukemia cells isolated from an L1210 leukemia mouse model.{62528} It decreases the percentage of isolated peripheral blood lymphocytes expressing CD3, CD4, or CD19 when administered to mice at doses of 100 or 150 mg/kg.{62529} Cyclophosphamide (200 mg/kg) induces nephrotoxicity and hepatotoxicity in rats.{62530} It is teratogenic to embryos when administered to pregnant dams on day 11 of gestation at doses of 5, 10, or 20 mg/kg.{58493} Formulations containing cyclophosphamide have been used in the treatment of cancer and autoimmune disorders.
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