Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 4-amino-1-ß-D-arabinofuranosyl-2(1H)-pyrimidinone-4,5,6-13C3
Purity: ≥95%
Formula Markup: C6[13C3]H13N3O5
Formula Weight: 246.2
Notes: Cytarabine-13C3 (ara-C-13C3) is intended for use as an internal standard for the quantification of ara-C (Item No. 16069) by GC- or LC-MS. Ara-C is a nucleoside analog and prodrug form of the DNA polymerase inhibitor ara-CTP.{48724} It is triphosphorylated to ara-CTP by the successive actions of deoxycytidine kinase, deoxycytidylate kinase, and nucleoside diphosphate kinase.{48725} Ara-C inhibits proliferation of HL-60, ML-1, Raji, and Jurkat human leukemia cell lines with IC50 values of 37, 17, 16, and 72 nM, respectively.{48726} It induces cell cycle arrest at the G0/G1 phase in HL-60 cells when used at concentrations of 2.5 and 15 µM.{48724} Ara-C (75 mg/kg per day, i.p.) reduces tumor growth and increases tumor caspase-3 activity in an MOLM-13 mouse xenograft model.{48727} It also increases survival and reduces brain herpesvirus titers in infected rats when administered subcutaneously at doses of 80 and 320 mg/kg.{48728} Formulations containing ara-C have been used in the treatment of acute myeloid leukemia.
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