Shelf life (days): 1460.0
Formulation: A solid
Formal Name: (3R,3aS,6aR)-N-[(1S,2R)-3-[[(4-aminophenyl)sulfonyl][2-(methyl-d3)propyl-1,1,2,3,3,3-d6]amino]-2-hydroxy-1-(phenylmethyl)propyl]-carbamic acid, hexahydrofuro[2,3-b]furan-3-yl ester
Purity: ≥99% deuterated forms (d1-d9)
Formula Markup: C27H28D9N3O7S
Formula Weight: 556.71924
CAS Number: 1133378-37-6
Notes: Darunavir-d9 is intended for use as an internal standard for the quantification of darunavir (Item Nos. 15866 / 31083) by GC- or LC-MS. Darunavir is an HIV-1 protease inhibitor.{26076} It is active against HIV-1LAI in MT-2 cells (IC50 = 3 nM) with a cytotoxic concentration (CC50) of 74.4 μM. Darunavir is also active against wild-type and multidrug-resistant clinical isolates of HIV-1 in phytohemagglutinin-activated peripheral blood mononuclear cells (PHA-PBMCs; IC50s = 3 and 3-29 nM, respectively). It inhibits cell-free diffusion and cell-to-cell spread of HIV-1 in Jurkat cell populations (IC50s = 2.5 and 2.8 nM, respectively).{26075} Formulations containing darunavir have been used in combination therapy for the treatment of HIV.
English
Deutsch
