Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 3-[[(3S,5S)-5S-[[(aminosulfonyl)amino]methyl]-3-pyrrolidinyl]thio]-6S-[(1R)-1-hydroxyethyl]-4R-(methyl-d3)-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-4-d1-2-carboxylic acid, monosodium salt
Purity: ≥99% deuterated forms (d1-d4)
Formula Markup: C15H19D4N4O6S2 / Na
Formula Weight: 446.51249
Notes: Doripenem-d4 is intended for use as an internal standard for the quantification of doripenem (Item No. 16934) by GC- or LC-MS. Doripenem is a broad-spectrum antibiotic in the β-lactam subclass known as carbapenems.{27718,27720} It is active against Gram-negative and Gram-positive bacteria, including S. aureus, S. pneumoniae, E. coli, and K. pneumoniae (MICs = 0.03-0.06, 0.016-0.06, P. aeruginosa respiratory tract infection when administered at a dose of 100 mg/kg per day.{42572} It inhibits bacterial cell wall synthesis by forming stable acyl enzymes with penicillin-binding proteins, thereby inactivating them.{27720} Formulations containing doripenem have been used in the treatment of bacterial infections.
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