Shelf life (days): 1460.0
Formulation: A solid
Formal Name: (4S,6S)-4-((ethyl-d5)amino)-5,6-dihydro-6-methyl-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide, monohydrochloride
Purity: ≥99% deuterated forms (d1-d5)
Formula Markup: C10H11D5N2O4S3 / HCl
Formula Weight: 365.93406
CAS Number: 2749856-75-3
Notes: Dorzolamide-d5 is intended for use as an internal standard for the quantification of dorzolamide (Item No. 14616) by GC- or LC-MS. Dorzolamide is an inhibitor of carbonic anhydrase (CA), inhibiting CAII, CAV, CAVI, CAIX, CAXII, CAXIII, and CAXIV with Ki values ranging from 3.5 to 52 nM.{23433,23435,23434} It is selective for these isoforms over CAI, CAIII, and CAIV (Kis = 50, 8, and 8.5 μM, respectively).{23433} Dorzolamide inhibits carbonic anhydrase in isolated rabbit iris-ciliary body by 87% when used at a concentration of 0.02%.{23434} It also reduces intraocular pressure in an α-chymotrypsin-treated rabbit model of ocular hypertension and in normotensive rabbits when applied topically at a concentration of 0.5%.{23434} Formulations containing dorzolamide have been used in the treatment of glaucoma.{23432,23436}
English
Deutsch
