Shelf life (days): 1460.0
Formulation: A solid
Formal Name: (4aR,4bS,6aS,7S,9aS,9bS,11aR)-N-(2,5-bis(trifluoromethyl)phenyl-1,2,3,4,5,6-13C6)-4a,6a-dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinoline-7-carboxamide
Purity: ≥98%
Formula Markup: C21[13C]6H30F6N2O2
Formula Weight: 534.5
CAS Number: 1217685-27-2
Notes: Dutasteride-13C6 is intended for use as an internal standard for the quantification of dutasteride (Item No. 15956) by GC- or LC-MS. Dutasteride is a dual inhibitor of 5α-reductase types I and II (Kis = 6 and 7 nM, respectively).{25831,25832,43107} Its inhibition is time-dependent with apparent Ki values of 17 and 4.3 nM at 10- and 30-minute reaction times, respectively.{25831} Dutasteride decreases prostate weight in a rat model of benign prostatic hypertrophy induced by testosterone after castration when administered daily for 28 days at doses of 0.045 mg/kg as a solution or 0.756 mg/kg in subcutaneous microspheres.{43105} It also decreases prostate weight in large probasin-large T antigen mice, a transgenic model of prostate cancer.{43106} Formulations containing dutasteride have been used in the treatment of benign prostatic hyperplasia.
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