Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl-2,2,3,3,5,5,6,6-d8)-1,8-naphthyridine-3-carboxylic acid, monohydrochloride
Purity: ≥99% deuterated forms (d1-d8)
Formula Markup: C15H9D8FN4O3 / HCl
Formula Weight: 364.828163
CAS Number: 2930288-95-0
Notes: Enoxacin-d8 is intended for use as an internal standard for the quantification of enoxacin (Item No. 16956) by GC- or LC-MS. Enoxacin is a fluoroquinolone antibiotic.{47756,27493,52851,54817} It is active against clinical isolates of a variety of Gram-positive and Gram-negative bacteria, including S. aureus, E. coli, K. pneumoniae, P. aeruginosa, and S. marcescens (MIC50s = 1, 0.12, 0.25, 0.5, and 1 mg/L, respectively).{47756} Enoxacin inhibits S. aureus DNA gyrase supercoiling activity and topoisomerase IV DNA decatenation (IC50s = 126 and 26.5 µg/ml, respectively).{27493} It increases survival in mouse models of systemic S. aureus, E. coli, K. pneumoniae, P. aeruginosa, and S. marcescens infection with ED50 values of 15.1, 2.2, 4.1, 120.3, and 7.6 mg/kg, respectively.{52851} Enoxacin (4 and 8 mg/kg per day) also reduces tumor growth in a 143B human osteosarcoma mouse xenograft model.{54817} Formulations containing enoxacin have previously been used in the treatment of urinary tract infections and gonorrhea.
English
Deutsch
