Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 2-(2,3-dichloro-4-(2-methylenebutanoyl-3,3,4,4,4-d5)phenoxy)acetic acid
Purity: ≥99% deuterated forms (d1-d5)
Formula Markup: C13H7Cl2D5O4
Formula Weight: 308.16768
CAS Number: 1330052-59-9
Notes: Ethacrynic acid-d5 is intended for use as an internal standard for the quantification of ethacrynic acid (Item No. 19536) by GC- or LC-MS. Ethacrynic acid is a loop diuretic with anticancer activity.{53194,33064,33063} It inhibits the Na-K-2Cl (NKCC) cotransporter in duck erythrocytes (IC50 = 0.18 mM) and ATP-dependent chloride uptake in rat renal plasma membrane vesicles when used at a concentration of 0.3 mM.{53194,33062} Ethacrynic acid also inhibits glutathione S-transferase P1-1 (GSTP1-1) and GSTA3-3 (IC50s = 4.9 and ~0.4 μM, respectively), and inhibits Wnt/β-catenin signaling in a cell-based reporter assay.{33064,41510} It is cytotoxic to primary chronic lymphocytic leukemia cells (IC50 = 8.56 μM), as well as MCF-7, MDA-MB-231, and 4T1 cancer cells (IC50s = 45.53, 39.64, and 25.23 μM, respectively).{33064,33063} Ethacrynic acid (250 μg per day) increases tumor growth reduction induced by the EGFR family inhibitors afatinib (Item Nos. 11492 / 21567 ) or neratinib (Item No. 18404) in a 4T1 murine breast cancer model.{33063} Formulations containing ethacrynic acid have been used in the treatment of edema.
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