Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 4-[[6-amino-5-bromo-2-[(4-cyanophenyl)amino]-4-pyrimidinyl]oxy]-3,5-di(methyl-d3)-benzonitrile
Purity: ≥99% deuterated forms (d1-d6)
Formula Markup: C20H9BrD6N6O
Formula Weight: 441.3133
CAS Number: 1142096-06-7
Notes: Etravirine-d6 is intended for use as an internal standard for the quantification of etravirine (Item No. 20946) by GC- or LC-MS. Etravirine is a non-nucleoside reverse transcriptase inhibitor (NNRTI).{32936} It is active against the wild-type HIV-1 strains LAI, SF2, and Ba-L (EC50s = 1.4-4.8 nM) but not the HIV-2 strain ROD (EC50 = 3,479 nM). Etravirine is also active against 18 HIV-1 strains carrrying NNRTI resistance-associated mutations (EC50s = <5 nM). Etravirine (5 μM) increases intracellular processing of the viral polyproteins Gag and Gag-Pol and decreases viral particle production in HEK293T cells transfected with a plasmid encoding the NL4.3 infectious molecular clone of HIV-1.{32937} Formulations containing etravirine have been used in the treatment of HIV-1 infection.
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