Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 42-O-(2-hydroxyethyl-1,1,2,2-d4)-rapamycin
Purity: ≥99% deuterated forms (d1-d4); ≤1% d0
Formula Markup: C53H79D4NO14
Formula Weight: 962.3
CAS Number: 1338452-54-2
Notes: Everolimus-d4 is intended for use as an internal standard for the quantification of everolimus (Item No. 11597) by GC- or LC-MS. Everolimus is a hydroxyethyl ether form of rapamycin (Item No. 13346) that inhibits mTOR signaling through both mTORC1 and mTORC2 when added to cells at 20 nM.{24850,24847} It is orally available and shows improved pharmacokinetics and pharmacodynamics over rapamycin.{24847} Through its inhibition of mTOR, everolimus inhibits cell proliferation, metabolism, and angiogenesis in certain types of cancer.{24849,24846} It also acts as an immunosuppressive agent in the context of organ transplantation.
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