Shelf life (days): 1460.0
Formulation: A solid
Formal Name: (Z)-2-((3R,4S,5S,8S,9S,10S,11R,13R,14S,16S)-16-acetoxy-3,11-dihydroxy-4,8,10,14-tetramethylhexadecahydro-17H-cyclopenta[a]phenanthren-17-ylidene)-6-(methyl-d3)hept-5-enoic-7,7,7-d3 acid
Purity: ≥99% deuterated forms (d1-d6)
Formula Markup: C31H42D6O6
Formula Weight: 522.8
Notes: Fusidic acid-d6 is intended for use as an internal standard for the quantification of fusidic acid (Item No. 14825) by GC- or LC-MS. Fusidic acid is a fusidane antibiotic originally isolated from F. coccineum.{54000} It is active against the Gram-positive bacteria S. aureus, S. pyogenes, C. diphtheriae, B. subtilis, and C. tetani (MIC50s = 0.01-20 µg/ml) but not the Gram-negative bacteria E. coli, S. typhimurium, and P. vulgaris or the fungi C. albicans and A. fumigatus (MIC50s = >100 µg/ml for all).{54001} Fusidic acid inhibits ribosomal recycling and protein translocation, processes mediated by elongation factor G (EF-G), in isolated E. coli ribosomes (IC50s = ~0.1 and ~200 µM, respectively).{54002} Topical administration of fusidic acid (2%) reduces the number of skin colony forming units (CFUs) and levels of TNF-α and IL-6 in a mouse model of methicillin-resistant S. aureus (MRSA) skin wound infection.{54003}
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