Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 2-amino-1,9-dihydro-9-[[2-hydroxy-1-(hydroxymethyl-d2)ethoxy-1,2,2-d3]methyl]-6H-purin-6-one
Purity: ≥99% deuterated forms (d1-d5)
Formula Markup: C9H8D5N5O4
Formula Weight: 260.3
CAS Number: 1189966-73-1
Notes: Ganciclovir-d5 is intended for use as an internal standard for the quantification of ganciclovir (Item Nos. 13853 / 37487) by GC- or LC-MS. Ganciclovir is an active metabolite of the prodrug valganciclovir (Item No. 13875) and an antiviral nucleoside derivative of 2’-deoxyguanosine (Item No. 9002864).{51563,22180} It reduces human, monkey, mouse, and guinea pig CMV replication in plaque reduction assays (EC50s = 1.3-70 µM).{22180} Topical application of ganciclovir (0.15%) decreases disease severity and corneal leukocyte infiltration in a cat model of ocular feline herpesvirus-1 (FHV-1) epithelial infection.{51566} Ganciclovir (15 mg/kg) prevents allograft histologic injury and natural killer (NK) and myeloid cell infiltration in a mouse model of murine CMV infection with renal transplantation.{51565} It induces tumor regression in a K-BALB murine sarcoma model using a mixed population of cells, which are positive or negative for expression of the gene encoding herpes simplex virus (HSV) thymidine kinase (TK).{51564} Formulations containing ganciclovir have been used in the treatment and prevention of CMV infections.
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