Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 2'-deoxy-2',2'-difluoro-cytidine-2-13C-1,3-15N2, monohydrochloride
Purity: ≥98%
Formula Markup: C8[13C]H11F2N[15N2]O4 / HCl
Formula Weight: 302.6
CAS Number: 2757566-59-7
Notes: Gemcitabine-13C,15N2 is intended for use as an internal standard for the quantification of gemcitabine (Item Nos. 11690 / 9003096) by GC- or LC-MS. Gemcitabine is an active metabolite of the gemcitabine prodrugs NUC-1031 (Item No. 9003247) and gemcitabine elaidate (Item No. 28303) and a prodrug form of gemcitabine di- and triphosphates.{43517,47590,52668} Gemcitabine is phosphorylated by intracellular kinases to the intermediate metabolite gemcitabine monophosphate (Item No. 31726) and the active di- and triphosphate forms.{52668} It is cytotoxic to HepG2 hepatocellular carcinoma and A549 non-small cell lung cancer (NSCLC) cells (IC50s = 5.2 and 16 nM, respectively) and inhibits tumor growth in various breast, colon, lung, and pancreatic cancer mouse xenograft models.{40343} Gemcitabine (12 mg/kg) sensitizes tumors to antibodies targeting programmed cell death protein 1 (PD-1), decreases the number of tumor-infiltrating regulatory T cells (Tregs), and increases survival in an MC-38 syngeneic mouse model of colon carcinoma.{65688} Formulations containing gemcitabine have been used in the treatment of cancer.
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