Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 7-chloro-4,6-dimethoxy-2'-(methoxy-d3)-6'R-methyl-spiro[benzofuran-2(3H),1'S-[2]cyclohexene]-3,4'-dione
Purity: ≥99% deuterated forms (d1-d3)
Formula Markup: C17H14ClD3O6
Formula Weight: 355.78416
CAS Number: 1279033-22-5
Notes: Griseofulvin-d3 is intended for use as an internal standard for the quantification of griseofulvin (Item No. 19461) by GC- or LC-MS. Griseofulvin is a fungal metabolite that has been found in Penicillium and has diverse biological activities.{31422} It is active against clinical isolates of the dermatophytes T. rubrum, T. tonsurans, and M. canis (MICs = 0.0078-0.0156, 1-4, and 0.5-2 µg/ml, respectively).{59869} Griseofulvin binds to tubulin (Kd = 300 µM) and reduces the growth rate and shortening rate of isolated bovine brain microtubulin, indicating stabilization of microtubule dynamics, when used at concentrations ranging from 0.5 to 20 µM.{59870} It induces abnormal microtubule polymerization and cell cycle arrest at the G2/M phase in HT-29 cells when used at a concentration of 20 µM.{59871} Griseofulvin (30 mg/kg), alone or in combination with nocodazole (Item No. 13857), reduces tumor growth in a COLO 205 mouse xenograft model. Formulations containing griseofulvin have been used in the treatment of fungal infections.
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