Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: 2-chloro-5-nitrobenzanilide-10,11,12,13,14-d5
Purity: ≥99% deuterated forms (d1-d5)
Formula Markup: C13H4ClD5N2O3
Formula Weight: 281.7
Notes: The peroxisome proliferator-activated receptor γ (PPARγ) is the nuclear receptor responsible for transducing the therapeutic activity of the thiazolidinediones (TZDs). TZDs are a group of structurally related synthetic PPARγ agonists with antidiabetic actions in vivo.{7575,8224} Rosiglitazone is a prototypical TZD and has served as a reference compound for this class.{8241} There are many PPARγ agonists, including 15-deoxy-Δ12,14-prostaglandin J2 and azelaoyl PAF, which are naturally derived.{8461,8930} However, only a few antagonists have been reported.{8953} GW 9662 blocks the PPARγ-induced differentiation of monocytes to osteoclasts by >90% at a dose of 0.1 µM.{9318} It is therefore a much more potent antagonist than BADGE, which is another reported PPARγ antagonist.{9318}
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