Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: 4-[2-(dimethylamino)ethyl]-phenol
Purity: ≥95%
Formula Markup: C10H15NO
Formula Weight: 165.2
CAS Number: 539-15-1
Notes: Hordenine (Item No. 21626) is a naturally occurring alkaloid found in a variety of plants, most commonly germinated barley (Hordeum species) from which the name is derived, and is structurally classified as a phenethylamine.{33813,33816} It is biosynthesized by the step-wise double methylation of tyramine (Item No. 18601).{33815} Hordenine binds to and activates the dopamine D2 receptor (Ki = 13 µM) but antagonizes D2 receptor β-arrestin recruitment.{33814} It inhibits tyrosinase activity and expression at concentrations ≥ 50 µM resulting in reduced melanin accumulation in human melanocytes.{33816} Hordenine is present in significant amounts in beer and can be measured in serum in the free form, for up to 2 hours, and the glucuronidated form, for up to 6 hours, after beer consumption.{33817} This product is intended for research and forensic applications.
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