Shelf life (days): 1460.0
Formulation: A solid
Formal Name: L-serine-1,2,3-13C3
Purity: ≥95%
Formula Markup: [13C]3H7O3
Formula Weight: 108.1
CAS Number: 201595-68-8
Notes: L-Serine-13C3 is intended for use as an internal standard for the quantification of L-serine (Item No. 33561) by GC- or LC-MS. L-Serine is a non-essential amino acid.{57549} It is produced from 3-phosphoglycerate in a multistep biosynthesis catalyzed by phosphoglycerate dehydrogenase (PGDH), phosphoserine aminotransferase (PSAT), and phosphoserine phosphatase (PSP). L-Serine can also be derived from dietary sources, as well as protein and phospholipid turnover. Defective L-serine biosynthesis is associated with neural tube defects and deoxysphingolipid accumulation in patients with Neu-Laxova syndrome, a rare disease characterized by a mutation in PGDH.{57549,57550} Dysregulation of L-serine phosphorylation is associated with disease progression in patients with neurodegenerative diseases, including Alzheimer’s disease and amyotrophic lateral sclerosis.
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