Shelf life (days): 1460.0
Formulation: A solid
Formal Name: L-tryptophan-2,4,5,6,7-d5
Purity: ≥99% deuterated forms (d1-d5)
Formula Markup: C11H7D5N2O2
Formula Weight: 209.25556
CAS Number: 62595-11-3
Notes: L-Tryptophan-d5 is intended for use as an internal standard for the quantification of L-tryptophan (Item No. 29600) by GC- or LC-MS. L-Tryptophan is an essential amino acid.{53275} It serves as a substrate for tryptophan hydroxylase (TPH), indoleamine-2,3-dioxygenase (IDO), and tryptophan-2,3-dioxygenase (TDO) for the biosynthesis of serotonin (5-HT; Item No. 14332) and kynurenine (Item No. 11305).{53276} L-Tryptophan is also metabolized by enteric bacteria expressing tryptophanase into indole, pyruvate, and ammonia.{53033} It increases 5-HT, 5-hydroxy-L-tryptophan (5-HTP), and 5-hydroxy indole-3-acetic acid (5-HIAA) levels in the diencephalon of rats when administered at a dose of 300 mg/kg.{53277} L-Tryptophan decreases immobility time in the forced swim test in rats when administered at doses of 4 and 20 mg/kg per day for eight weeks.{53278}
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