LEE011, CAS 1211441-98-3

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: 7-cyclopentyl-N,N-dimethyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide

Purity: ≥95%

Formula Markup: C23H30N8O

Formula Weight: 434.5

CAS Number: 1211441-98-3

Notes: LEE011 is a cyclin-dependent kinase (CDK) inhibitor that targets cyclin D1/CDK4 and cyclin D3/CDK6 at nanomolar concentrations.{28690,28691,28692} It inhibits retinoblastoma protein phosphorylation, which prevents CDK-mediated G1-S phase transition, arresting the cell cycle in the G1 phase, suppressing DNA synthesis, and inhibiting cancer cell growth.{28692} LEE011 has been shown to reduce proliferation in 12 of 17 human neuroblastoma-derived cell lines by inducing cytostasis (mean IC50 = 306 nM in sensitive lines).{28692}

• SKU: CAY17666-50
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 17666-50
• Package Unit: 50 mg
• Quantity Unit: STK
• Application: Reinstoffe