Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 4-[(4-cyanophenyl)-1H-1,2,4-triazol-1-ylmethyl]-benzonitrile-2,3,5,6-d4
Purity: ≥99% deuterated forms (d1-d4)
Formula Markup: C17H7D4N5
Formula Weight: 289.32718
CAS Number: 1133712-96-5
Notes: Letrozole-d4 is intended for use as an internal standard for the quantification of letrozole (Item No. 11568) by GC- or LC-MS. Letrozole is a potent, cell-permeable inhibitor of aromatase (IC50 = 2 nM).{23490} It inhibits proliferation of estrogen receptor-positive (ER+) MCF-7 cells when used alone at concentrations ranging from 0.1 to 100 nM and when used at a concentration of 10 nM in combination with testosterone or 4-androstene-3,17-dione.{46076} It also reduces matrix metalloproteinase-2 (MMP-2) and MMP-9 levels in MCF-7 cells when used at a concentration of 10 nM. Letrozole (10 µg per day) reduces tumor growth in an MCF-7Ca ovariectomized-mouse xenograft model.{46077} Formulations containing letrozole have been used in the treatment of postmenopausal breast cancer.{23489}
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