Shelf life (days): 365.0
Formulation: A solution in ethanol
Formal Name: 6R-[[(2R)-2-amino-2-carboxyethyl]thio]-5S-hydroxy-7E,9E,11Z,14Z-eicosatetraenoic-19,19,20,20,20-d5 acid
Purity: ≥99% deuterated forms (d1-d5)
Formula Markup: C23H32D5NO5S
Formula Weight: 444.64
CAS Number: 1240398-14-4
Notes: Leukotriene E4-d5 (LTE4-d5) is intended for use as an internal standard for the quantification of LTE4 (Item No. 20410) by GC- or LC-MS. LTE4 is produced by the action of dipeptidase on LTD4, leaving only the cysteinyl group still attached to the fatty acid backbone.{2236} It is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A).{394} LTE4 is considerably less active (8 to 12-fold) than LTC4 in the biological activities characteristic of cysteinyl leukotrienes.{2236,396} Unlike LTC4 and LTD4, LTE4 accumulates in both plasma and urine. Therefore, urinary excretion of LTE4 is most often used as an indicator of asthma.{1815,865,2064} In humans, basal levels of LTE4 range from 1-100 pg/mg creatinine. In asthmatic patients, urinary LTE4 levels increase to 80-1,000 pg/mg creatinine.{865}
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