Shelf life (days): 1460.0
Formulation: A solid
Formal Name: rel-N-[(1R,3R,4R)-4-[[2-(2,6-dimethylphenoxy)acetyl]amino]-3-hydroxy-5-phenyl-1-(phenylmethyl)pentyl]tetrahydro-a-[1-(methyl-d3)ethyl-1,2,2,2-d4]-2-oxo-1(2H)-pyrimidineacetamide-a-d
Purity: ≥99% deuterated forms (d1-d8)
Formula Markup: C37H40D8N4O5
Formula Weight: 636.9
CAS Number: 1322625-54-6
Notes: Lopinavir-d8 is intended for use as an internal standard for the quantification of lopinavir (Item No. 13854) by GC- or LC-MS. Lopinavir is a potent HIV-1 protease inhibitor (Ki = 1.3 pM for wild-type enzyme).{24199} It inhibits the replication of clinical isolates of HIV-1 (EC50s = 5-52 nM). Lopinavir reduces the infectious virus yield and viral RNA copy numbers in the culture supernatant of Vero E6 cells infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2; EC50s = 26.63 and 26.10 µM, respectively).{53655} It reduces lung and kidney viral load, bronchointerstitial pneumonia, and pulmonary inflammatory cell infiltration in a marmoset model of Middle East respiratory syndrome coronavirus (MERS-CoV) infection when administered in combination with ritonavir (Item No. 13872).{53656}
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