Formulation: A solid
Formal Name: N-[5-(aminosulfonyl)-1,3,4-thiadiazol-2-yl]-acetamide-2,2,2-d3
Purity: ≥99% deuterated forms (d1-d3)
Formula Markup: C4H3D3N4O3S2
Formula Weight: 225,3
Shelf life (days): 1460
CAS Number: 1189904-01-5
Notes: Acetazolamide-d3 is intended for use as an internal standard for the quantification of acetazolamide by GC- or LC-MS. Acetazolamide is an inhibitor of carbonic anhydrase I (CAI), CAII, CAIX, and CAXII (Kis = 310, 12, 25, and 5.7 nM, respectively, for the human enzymes).{36212} It inhibits the migration and invasion of Caki-1, Caki-2, and ACHN renal carcinoma cells when used at a concentration of 10 µM.{72187} Acetazolamide (5.6 mg/kg per day) increases currents in calcium-activated potassium channels in patch clamp assays using skeletal muscle tissues isolated from potassium-deficient rats.{36214} It induces vasodilation and increases cerebral, renal, and hepatic blood flow and blood oxygen levels in normotensive rabbits when administered at a dose of 12 mg/kg.{72188} Formulations containing acetazolamide have been used in the treatment of edema, open-angle glaucoma, epilepsy, and acute mountain sickness.
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