Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 2-[[(Z)-[1-(2-amino-4-thiazolyl)-2-[[(2S,3S)-2-methyl-4-oxo-1-sulfo-3-azetidinyl]amino]-2-oxoethylidene]amino]oxy]-2-(methyl-d3)-propanoic-3,3,3-d3 acid
Purity: ≥99% deuterated forms (d1-d6)
Formula Markup: C13H11D6N5O8S2
Formula Weight: 441.47134
CAS Number: 1127452-94-1
Notes: Aztreonam-d6 is intended for use as an internal standard for the quantification of aztreonam (Item No. 19784) by GC- or LC-MS. Aztreonam is a synthetic β-lactam antibiotic of the monobactam class.{31705} It is active against clinical isolates of E. coli, S. marcescens, P. aeruginosa, Klebsiella species, Proteus species, and Enterobacter species (MICs = S. pneumoniae, B. fragilis, and S. faecalis (MICs = >100 µg/ml for all). It interferes with peptidoglycan synthesis in the bacterial cell wall of the Gram-negative bacteria E. coli, P. vulgaris, E. cloacae, K. pneumoniae, and P. aeruginosa by inhibiting penicillin-binding protein 3 (PBP3; IC100 = 0.1 µg/ml for all). It increases survival in mice with systemic Gram-negative bacterial infections (ED50s = 0.1-24.7 mg/kg). Formulations containing aztreonam have been used in the treatment of P. aeruginosa infections in individuals with cystic fibrosis.
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