DB2313 (hydrochloride)

Shelf life (days): 1460.0

Formulation: A solid

Formal Name: 2,2'-[(2-fluoro-1,3-phenylene)bis(methyleneoxy-4,1-phenylene)]bis[N-(1-methylethyl)-1H-benzimidazole-6-carboximidamide, hydrochloride

Purity: ≥98%

Formula Markup: C42H41FN8O2 / XHCl

Formula Weight: 708.826063

Notes: DB2313 is an inhibitor of the transcription factor PU.1 (IC50 = 14 nM).{69301} Long-term exposure of DB2313 (300 nM) to Kit+/Sca-1+/Lin- hematopoietic stem progenitor cells (KSL-HSPCs) reduces colony formation. DB2313 (700 nM) decreases ovalbumin-induced reprogramming of isolated mouse neutrophils into antigen-presenting cells.{69302} It decreases tumor growth, weight, and volume in a U87MG glioblastoma multiforme mouse xenograft model when administered at a dose of 10 mg/kg per day.{69303}

• SKU: CAY35021-1
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 35021-1
• Package Unit: 1 mg
• Quantity Unit: STK
• Application: Reinstoffe