Ganglioside GD1a Monoclonal Antibody (Clone MOG35)

Ganglioside GD1a Monoclonal Antibody (Clone MOG35)
SKU
CAY38295
Packaging Unit
100 µg
Manufacturer
Cayman Chemical

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Shelf life (days): 1095.0

Formulation: 100 µg of protein G-purified monoclonal antibody

Immunogen: Ganglioside GD1a-KLH

Clone Designation: MOG35

Target specificity: Species

Cross Reactivity: + Ganglioside GD1a; - Ganglioside GD1b; - Ganglioside GD3; - Ganglioside GM1; - Ganglioside GM2; - Ganglioside GM3; - Ganglioside GQ1b; - Sulfatides

Formula Weight: 0.0

Notes: Ganglioside GD1a (Item Nos. 31591 / 15585 / 31707) is a sialic acid-containing glycosphingolipid that has been found in brain, erythrocytes, bone marrow, testis, spleen, and liver, as well as in serum lipoproteins.{54332,54333} It is formed by the transfer of N-acetylneuraminic acid (Neu5Ac; Item No. 16091) to the precursor ganglioside GM1a by CMP-N-acetylneuraminate-β-galactosamide-α-2,3-sialyltransferase 2 (ST3Gal-II).{68400} It functions as a toll-like receptor 2 (TLR2) co-receptor in isolated human monocytes, colocalizing with TLR2 and enhancing the binding of type IIb E. coli enterotoxin (LT-IIb-B5) to TLR2.{25484} Ganglioside GD1a also mediates polyomavirus entry into host cells.{68401} Ganglioside GD1a is shed into the tumor microenvironment from the surface of tumor cells, where it influences tumor-host cell interactions to promote tumor cell proliferation, invasion, and metastasis, as well as increases VEGF-induced proliferation of human umbilical vein endothelial cells (HUVECs). A monoclonal antibody targeting ganglioside GD1a and ganglioside GT1b (Item Nos. 31712 / 15588 / 31592) inhibits axon regeneration in a mouse model of sciatic nerve crush-induced peripheral nervous system injury.{68402} Ganglioside GD1a accumulates in the CNS of patients with galactosialidosis, a lysosomal storage disorder.{43703} Cayman's Ganglioside GD1a Monoclonal Antibody (Clone MOG35) binds to Ganglioside GD1a (bovine brain) (Item No. 15585) with ka, kd, and KD values of 40,200 M-1s-1, 0.078 s-1, and 2.01 µM, respectively, as determined by surface plasmon resonance (SPR). It can be used for dot blot, ELISA, immunofluorescence (IF), and TLC immunostaining applications.
More Information
SKU CAY38295
Manufacturer Cayman Chemical
Manufacturer SKU 38295-100
Package Unit 100 µg
Quantity Unit STK
Reactivity Various species
Clonality Monoclonal
Application Immunofluorescence, ELISA, Dot Blot, Reinstoffe
Isotype IgG2b
Host Mouse
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