Notes: L202 is an ionizable cationic lipid (pKa = 6.04) that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA.{51307} Intramuscular administration of LNPs containing L202 and encapsulating nucleoside-modified mRNA encoding pre-fusion stabilized severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike glycoprotein, also known as surface glycoprotein, increase plasma levels of IgG antibodies targeting SARS-CoV-2 spike glycoprotein in mice and cynomolgus monkeys.