Formulation: A solid
Formal Name: 1,2,3,4,10,14b-hexahydro-2-(methyl-d3)-pyrazino[2,1-a]pyrido[2,3-c][2]benzazepine
Purity: ≥99% deuterated forms (d1-d3)
Formula Markup: C17H16D3N3
Formula Weight: 268,4
Shelf life (days): 1460
CAS Number: 1216678-68-0
Notes: Mirtazapine-d3 is intended for use as an internal standard for the quantification of mirtazapine by GC- or LC-MS. Mirtazapine is a tetracyclic antidepressant.{72177} It selectively binds to the histamine H1 receptor, α2A- and α2C-adrenergic receptors, and the serotonin (5-HT) receptor subtypes 5-HT2A and 5-HT2C (Kis = 1.6, 20, 18, 69, and 39 nM, respectively) over the α1-adrenergic receptor, 5-HT7, norepinephrine transporter (NET), and dopamine D1, -D2, and -D3 receptors (Kis = 608, 265, 1,640, 4,167, >5,454, and 5,723 nM, respectively). Mirtazapine inhibits tryptamine-induced cyanosis, bilateral convulsions, and backward locomotion in rats (ED50s = 0.8, 0.32, and 0.5 mg/kg, respectively). It prevents the acquisition and reinstatement of cocaine-induced place preference in rats.{53850} Mirtazapine (40 mg/kg) decreases immobility time in the forced swim test in mice.{72176} Formulations containing mirtazapine have been used in the treatment of major depressive disorder. This product is also available as an analytical reference standard (Item Nos. 31762 / 21126).
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