Formulation: A solution in ethanol
Formal Name: oleic-1,2,3,7,8-13C5 acid
Purity: ≥95%
Formula Markup: C13[13C]5H34O2
Formula Weight: 287,4
Shelf life (days): 730
CAS Number: 1255644-48-4
Notes: Oleic acid-13C5 is intended for use as an internal standard for the quantification of oleic acid (Item Nos. 90260 / 24659) by GC- or LC-MS. Oleic acid is a monounsaturated fatty acid and a major component of membrane phospholipids that has been found in human plasma, cell membranes, and adipose tissue.{3964,42296} It contributes approximately 17% of the total fatty acids esterified to phosphatidylcholine, the major phospholipid class in porcine platelets.{3964} Oleic acid inhibits collagen-stimulated platelet aggregation by approximately 90% when used at a concentration of 10 µg/ml. It also inhibits fMLF-induced neutrophil aggregation and degranulation by 55 and 68%, respectively, when used at a concentration of 5 µM, similar to arachidonic acid (Item Nos. 90010 / 90010.1 / 10006607).{2095} Oleic acid (60 µM) induces release of intracellular calcium in human platelets.{4198} In vivo, oleic acid increases TNF-α, IL-8, IL-6, and IL-1β production, neutrophil accumulation, and apoptotic and necrotic cell death in mouse lung and has been used to induce lung injury in a mouse model of acute respiratory distress syndrome (ARDS).{42296}
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