Quarfloxin, CAS 865311-47-3

Shelf life (days): 1460.0

Formulation: A solid

Formal Name: 5-fluoro-N-[2-[(2S)-1-methyl-2-pyrrolidinyl]ethyl]-3-oxo-6-[3-(2-pyrazinyl)-1-pyrrolidinyl]-3H-benzo[b]pyrido[3,2,1-kl]phenoxazine-2-carboxamide

Purity: ≥98%

Formula Markup: C35H33FN6O3

Formula Weight: 604.673563

CAS Number: 865311-47-3

Notes: Quarfloxin is an inhibitor of RNA polymerase I-mediated transcription.{51352} It binds to G-quadruplex DNA and inhibits the interaction between ribosomal DNA G-quadruplexes and nucleolin, a nucleolar protein required for RNA polymerase I-mediated transcription. Quarfloxin (10 µM) induces nucleolin mislocalization from the nucleoli to the nucleoplasm in A549 cells. It induces apoptosis in A549 and HL-60 cells when used at a concentration of 5 µM. Quarfloxin (5 mg/kg) reduces tumor growth in MDA-MB-231 breast and MiaPaCa-2 pancreatic cancer mouse xenograft models.

• SKU: CAY36552-1
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 36552-1
• Package Unit: 1 mg
• Quantity Unit: STK
• Application: Reinstoffe