Shelf life (days): 730.0
Formulation: A crystalline solid
Formal Name: (aE,1'R,6'R,7'S,8'aS)-6'-ethyl-1,2,2',3',6',7',8',8'a-octahydro-a-(methoxymethylene)-2-oxo-spiro[3H-indole-3,1'(5'H)-indolizine]-7'-acetic acid, methyl ester
Purity: ≥98%
Formula Markup: C22H28N2O4
Formula Weight: 384.4688
CAS Number: 76-66-4
Notes: Rhyncophylline is an alkaloid that has been found in U. rhyncophylla and has diverse biological activities.{62974,62975,62976,62977} It inhibits aggregation of isolated rabbit platelets induced by arachidonic acid (Item Nos. 90010 / 90010.1 / 10006607), collagen, or ADP (IC50s = 0.72, 0.74, and 0.67 mmol/L).{62974} In vivo, rhyncophylline (0.25 mg/kg) decreases the number of sleep-wake cycles and increases total sleep time and rapid eye movement (REM) sleep in rats.{62975} It reduces infarct volume and reverses sensory-motor and spatial memory defects in a mouse model of stroke induced by middle cerebral artery occlusion (MCAO) when administered at a dose of 40 mg/kg.{62976} Rhyncophylline (10 and 20 mg/kg) also reduces hippocampal production of reactive oxygen species (ROS) and malondialdehyde (MDA) levels and decreases escape latency in the Morris water maze test in a mouse model of Alzheimer’s disease induced by amyloid-β (1-42) (Aβ42).{62977}
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