Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 1,3-dihydro-1-(methyl-d3)-2H-imidazole-2-thione
Purity: ≥99% deuterated forms (d1-d3)
Formula Markup: C4H3D3N2S
Formula Weight: 117.1881
CAS Number: 1160932-07-9
Notes: Methimazole-d3 is intended for use as an internal standard for the quantification of methimazole (Item No. 23718) by GC- or LC-MS. Methimazole is an inhibitor of thyroid hormone synthesis.{37227,37226} It is a substrate for thyroid peroxidase that traps oxidized iodide, preventing its use by thyroglobulin for thyroid hormone synthesis. Methimazole (0.4 mg/kg) inhibits the absorption of radiolabeled iodide by the thyroid gland in rats by 80.9%.{37225} It reduces the incidence of lymphocytic thyroiditis in the insulin-dependent type 1 diabetic BB/W rat.{37224} Methimazole has been used to induce hypothyroidism in mice.{59786,59787} Formulations containing methimazole have been used in the treatment of hyperthyroidism.
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