Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 7-chloro-1,2,3,4-tetrahydro-2-methyl-3-[2-(methyl-d3)phenyl-3,4,5,6-d4]-4-oxo-6-quinazolinesulfonamide
Purity: ≥99% deuterated forms (d1-d7)
Formula Markup: C16H9D7ClN3O3S
Formula Weight: 372.87778
CAS Number: 2714484-71-4
Notes: Metolazone-d7 is intended for use as an internal standard for the quantification of metolazone (Item No. 15987) by GC- or LC-MS. Metolazone is a thiazide-like diuretic.{25930,23242} It inhibits the Na+/Cl- cotransporter (IC50 = 0.3 µM for the rat transporter) and human carbonic anhydrase VII (CAVII), CAXII, and CAXIII (Kis = 2.1, 5.4, and 15 nM, respectively). Metolazone (0.3 and 1 mg/kg) induces fluid loss and enhances captopril-induced decreases in blood pressure in spontaneously hypertensive rats.{62331} Formulations containing metolazone have been used in the treatment of high blood pressure.
English
Deutsch
