Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 1-(2-hydroxyethyl-1,1,2,2-d4)-2R-(hydroxymethyl)-3R,4R,5S-piperidinetriol
Purity: ≥99% deuterated forms (d1-d4)
Formula Markup: C8H13D4NO5
Formula Weight: 211.3
Notes: Miglitol-d4 is intended for use as an internal standard for the quantification of miglitol (Item No. 15014) by GC- or LC-MS. Miglitol is an inhibitor of α-glucosidases (IC50s = 0.35, 0.11, 1.3, and 1.2 µM for human lysosomal α-glucosidase and rat sucrase, maltase, and isomaltase, respectively).{22626} It is selective for human α- over β-glucosidase (IC50 = 84 µM). Miglitol (10 mg/kg) decreases blood glucose levels in sucrose-loaded Goto-Kakizaki (GK) type 2 diabetic rats.{49506} Dietary administration of miglitol (40 mg/100 g diet) for 8 weeks decreases changes in HbA1c levels compared with control rats fed a normal diet. Formulations containing miglitol have been used in the treatment of type 2 diabetes.
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