Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: 6-(1-piperidinyl-d10)-2,4-pyrimidinediamine 3-oxide
Purity: ≥99% deuterated forms (d1-d10)
Formula Markup: C9H5D10N5O
Formula Weight: 219.3
CAS Number: 1020718-66-4
Notes: Minoxidil-d10 is intended for use as an internal standard for the quantification of minoxidil (Item No. 15302) by GC- or LC-MS. Minoxidil is a pyrimidine derivative that was originally developed as an anti-hypertensive agent and unexpectedly found to stimulate hair growth. Minoxidil directly affects arteriolar smooth muscle to decrease vascular resistance in part by opening ATP-sensitive potassium channels.{24983,24984} It can activate cyclooxygenase 1 (AC50 = 80 μM), which is expressed in the dermal papilla of hair follicles, increasing prostaglandin E2 production in BALB/c 3T3 fibroblasts and human dermal papilla fibroblasts.{4171}
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