Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 4-(2-methoxyphenyl)-a-[(1-naphthalenyloxy)methyl-d2]-1-piperazineethan-a,ß,ß-d3-ol
Purity: ≥99% deuterated forms (d1-d5)
Formula Markup: C24H23D5N2O3
Formula Weight: 397.5211
CAS Number: 2747918-58-5
Notes: Naftopidil-d5 is intended for use as an internal standard for the quantification of naftopidil (Item No. 21122) by GC- or LC-MS. Naftopidil is an antagonist of α1-adrenergic receptors (α1-ARs; Kis = 3.7, 20, and 1.2 nM for α1A-, α1B-, and α1D-ARs, respectively).{33264} It is selective for α1-ARs over α2-ARs (Ki = 1,793 nM).{33266} Naftopidil inhibits norepinephrine-induced contractions in various blood vessels isolated from dog, rabbit, guinea pig, or rat with pA2 values ranging from 6.73 to 8.15.{33266} It reduces prostatic pressure and mean blood pressure in anesthetized dogs when administered at doses of 100 or 1,000 µg/kg.{59904} Naftopidil also inhibits the growth of androgen-sensitive LNCaP cells and androgen-insensitive PC3 cancer cells with IC50 values of 22.2 and 33.2 µM, respectively.{33265} Formulations containing naftopidil have been used in the treatment of benign prostatic hyperplasia.
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