Shelf life (days): 1460.0
Formulation: A solid
Formal Name: N6-(carboxymethyl)-L-lysine-2,6,6-d3
Purity: ≥99% deuterated forms (d1-d3)
Formula Markup: C8H13D3N2O4
Formula Weight: 207.2419
CAS Number: 2699607-49-1
Notes: Nε-(1-Carboxymethyl)-L-lysine-d3 (CML-d3) is intended for use as an internal standard for the quantification of CML (Item No. 16483) by GC- or LC-MS. CML is an advanced glycation end product (AGE), produced by the oxidative modification of glycated proteins during oxidative stress.{27118,27121,27119} Levels of CML increase with aging and during diabetes, cancer, vascular disease, and other pathologies marked by oxidative stress.{27118,27116,27115} CML activates the membrane-bound receptor for AGEs (RAGE), triggering signaling through MAPKs and NF-κB, whereas truncation of RAGE produces a soluble protein that binds CML and reduces signaling.{27120,27117}
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