Shelf life (days): 1460.0
Formulation: A solid
Formal Name: N5-[(dimethylamino)iminomethyl]-L-ornithine-d6, dihydrochloride
Purity: ≥99% deuterated forms (d1-d6)
Formula Markup: C8H12D6N4O2 / 2HCl
Formula Weight: 281.21192
CAS Number: 1313730-20-9
Notes: NG,NG-dimethyl-L-arginine-d6 (ADMA-d6) (hydrochloride) is intended for use as an internal standard for the quantification of NG,NG-dimethyl-L-arginine (Item No. 80230) by GC- or LC-MS. ADMA is an endogenous inhibitor of nitric oxide synthase (NOS).{52984,3249} It is formed from arginine by protein arginine methyltransferases (PRMTs) and degraded by dimethylarginine dimethylaminohydrolases (DDAHs) and alanine-glyoxylate aminotransferase 2 (AGXT2).{52984} ADMA levels are increased concomitant with an increase in blood pressure in Dahl salt-sensitive rats fed a high-salt diet.{3249} ADMA levels are increased in the plasma in a variety of endothelial dysfunction-related diseases, including hypertension, congestive heart failure, and end-stage renal disease.{52984,822,4517}
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