Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 3-pyridine-2,4,5,6-d4-carboxamide
Purity: ≥99% deuterated forms (d1-d4)
Formula Markup: C6H2D4N2O
Formula Weight: 126.2
CAS Number: 347841-88-7
Notes: Nicotinamide-d4 is intended for use as an internal standard for the quantification of nicotinamide (Item No. 11127) by GC- or LC-MS. Nicotinamide is an amide form of niacin, which is also known as vitamin B3, that can be biosynthesized in vivo or obtained through the diet.{63061} It is a precursor in the synthesis of the metabolic cofactor NAD+ and an inhibitor of sirtuin 1 (SIRT1; IC50 = <50 µM).{63062} Nicotinamide (10 µM) increases the activity of serine palmitoyltransferase (SPT) and the biosynthesis of ceramide, glucosylceramide, sphingomyelin, free fatty acids, and cholesterol in primary human keratinocytes.{63063} Nicotinamide (40 µM) induces apoptosis in SNU-398, SNU-739, and HepG2 hepatocellular carcinoma (HCC) cells, and it prevents the formation of neoplastic lesions in a diethylnitrosamine-induced mouse model of HCC.{63064} Unlike niacin, nicotinamide does not reduce plasma lipid levels or induce flushing.{63065,63066,63067}
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