Olaparib-d4

Shelf life (days): 1460.0

Formulation: A solid

Formal Name: 4-[[3-[[4-(cyclopropylcarbonyl-d4)-1-piperazinyl]carbonyl]-4-fluorophenyl]methyl]-1(2H)-phthalazinone

Purity: ≥99% deuterated forms (d1-d4)

Formula Markup: C24H19D4FN4O3

Formula Weight: 438.5

Notes: Olaparib-d4 is intended for use as an internal standard for the quantification of olaparib (Item No. 10621) by GC- or LC-MS. Olaparib is a potent inhibitor of PARP1 and PARP2 (IC50s = 5 and 1 nM, respectively) but is less effective against the PARP tankyrase-1 (IC50 = 1.5 µM).{24275} It can be used in cells and in animals, alone or in combination therapy with alkylating agents, to block base excision repair and increase cancer cell death.{24275,20554,20549,20553}

• SKU: CAY9002700-500
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 9002700-500
• Package Unit: 500 µg
• Quantity Unit: STK
• Application: GC-MS, LC-MS, Isotopenmarkierung