Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 6-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole-4,5,7-d3
Purity: ≥99% deuterated forms (d1-d3); ≤1% d0
Formula Markup: C17H16D3N3O3S
Formula Weight: 348.4
CAS Number: 934293-92-2
Notes: Omeprazole-d3 is intended for use as an internal standard for the quantification of omeprazole (Item No. 14880) by GC- or LC-MS. Omeprazole is an inhibitor of gastric H+/K+ ATPase (IC50 = 1.1 µM for the pig ATPase).{14045} It is a racemic mixture of esomeprazole (Item No. 17303) and (R)-omeprazole (Item No. 18874).{28643} Omeprazole (100 µM) decreases zymosan-induced oxygen free radical production in isolated human neutrophils.{51380} It is active against 17 strains of H. pylori (MIC50s = 12.5-50 µg/ml).{51382} It decreases histamine-induced acid secretion in dogs (ED50 = 0.35 µmol/kg).{51381} Formulations containing omeprazole have been used in the treatment of duodenal and gastric ulcers, gastroesophageal reflux disease, and erosive esophagitis.
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